Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

Optical coherence tomography (OCT) is an imaging technique used to obtain three-dimensional information on the retina. In this article, we evaluated structural neuro-retinal abnormalities, especially thickness in ganglion cell complex (GCC), patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The GCC MELAS was significantly thinner than that normal controls even when they had no history of transient homonymous hemianopia. There a negative correlation between disease duration. conclusion, OCT may be effective tool monitor predict progression patients.